![]() 3 In addition to alpha 1-blockade,Ĭarvedilol binds non-selectively to beta 1 and beta 2-adrenoceptors. Patients with insulin resistance, although strong evidence of a benefit is lacking. 3 It has been suggested that this may be preferable in carvedilol, reduce peripheral resistance by binding to alpha-adrenoceptors,Ĭausing vasodilation without affecting cardiac output. Bisoprolol is reported to be more cardioselective than metoprolol and atenolol. Preferred in patients with respiratory disease. atenolol, bisoprolol and metoprolol, have a greater affinity forīeta 1-adrenoceptors and are less likely to cause constriction of airways or peripheral vasculature and are ![]() propranolol, block beta 1 and beta 2-adrenoceptors equally.Ĭardioselective beta-blockers, e.g. carvedilol, also bind to alpha-adrenoceptors and prevent contraction of vascular smooth muscle.
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